Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about asap1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ASAP1 |
| Full Name | ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1 |
| Chromosome | 9q34.3 |
| Function | ASAP1 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1), also known as DDEF1 or AGAP2, is a member of the ArfGAP (ADP-ribosylation factor GTPase-activating protein) family. |
| Primary Expression | various cancers, making it a dual therapeutic target |
| UniProt ID | [Q9ULH0](https://www.uniprot.org/uniprot/Q9ULH0) |
| Ensembl ID | ENSG00000153317 |
| OMIM | 611752 |
| GeneCards | ASAP1 |
| Human Protein Atlas | ASAP1 |
| SH3 domain | Proline-rich motif interactions |
| Ankyrin repeats | Protein scaffolding |
| PH domain | Phosphoinositide binding |
| ArfGAP domain | GTPase activity |
| Brain | Particularly in regions affected in neurodegeneration |
| Associated Diseases | Alzheimer's Disease (AD |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["asap1 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ASAP1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ASAP1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning asap1 in their description or question text
No additional research found