Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arhgap24: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARHGAP24 |
| Full Name | Rho GTPase Activating Protein 24 |
| Aliases | MPRIP |
| Chromosome | 4q21.23 |
| Function | encodes a Rho GTPase-activating protein that plays critical roles in regulating the actin cytoskeleton, cell migration, and signal transduction. |
| Subcellular Localization | specific membrane microdomains, particularly at the leading edge of migrating cells and dendritic spines |
| Amino Acids | 200 aa |
| UniProt ID | [Q8TDR0](https://www.uniprot.org/uniprot/Q8TDR0) |
| Ensembl ID | ENSG00000116675 |
| GeneCards | ARHGAP24 |
| Human Protein Atlas | ARHGAP24 |
| Stress Fiber Formation | ARHGAP24 negatively regulates RhoA signaling to control actin stress fiber formation and contractility. |
| Lamellipodia and Filopodia | Through Rac1 and Cdc42 regulation, ARHGAP24 modulates the formation of lamellipodia (broad protrusions) and filopodia (thin, finger-like projections). |
| Cell Migration | ARHGAP24 expression correlates with reduced cell migration and invasion in multiple cancer types. |
| Cytokinesis | ARHGAP24 participates in abscission during cytokinesis through RhoA regulation. |
| Associated Diseases | Alzheimer's disease pathogenesis:[@xu2018][@koh2019] |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["arhgap24 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARHGAP24 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARHGAP24 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning arhgap24 in their description or question text
No additional research found