Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arh: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARH |
| Full Name | LDLR Adaptor Protein 1 |
| Chromosome | 1p36.22 |
| Protein Type | Adaptor Protein |
| Function | ARH (also known as LDLRAP1 - LDL Receptor Adaptor Protein 1) encodes an adaptor protein that links the LDL receptor (LDLR) to clathrin-mediated endocytosis. |
| UniProt ID | [Q9Y2T3](https://www.uniprot.org/uniprot/Q9Y2T3) |
| Ensembl ID | ENSG00000151552 |
| OMIM | 605747 |
| GeneCards | ARH |
| Human Protein Atlas | ARH |
| ApoE-mediated transport | astrocytes produce ApoE, neurons uptake cholesterol via LDLR/LRP1 |
| ARH's role | modulates LDLR/LRP1 trafficking, affecting neuronal cholesterol acquisition |
| ApoE-LDLR axis | ApoE4 isoform (major AD risk factor) binds to LDLR and LRP1; ARH modulates receptor trafficking |
| Amyloid-beta clearance | LRP1 mediates Aβ uptake and clearance; ARH affects this process |
| Cholesterol-Aβ interplay | Elevated brain cholesterol accelerates Aβ production; LDLR modulates cholesterol influx |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["arh gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARH | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARH | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning arh in their description or question text
No additional research found