Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about APOE-TREM2 interaction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neuroinflammatory response | regulates | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE-TREM2 Interaction Modulation | 0.741 | neurodegeneration | Mechanistic role of APOE in neurodegener |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852] | ["Ramirez G", "Hernandez D", "Teal A", " | Research square | 2026 | 0 |
| Neuroimmune Interactions in Neurodegeneration: The Role of Microglia in Alzheime [PMID:41750155] | ["Goyal Pradeep", "Baldaniya Lalji", "Ty | Brain sciences | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven Gamze; Gezegen Haşim; & | Acta neurologica Belgica | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Eicosapentaenoic acid attenuates heart failure with preserved ejection fraction [PMID:41655546] | Xie Y, He H, Li Y, Chen Q, Fu S et al. | Phytomedicine | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Aβ-Overlapping Ectodomain Binding of the Clinical-Stage TREM2 Agonist VG-3927. [PMID:41867790] | Cho S, Gabr MT | bioRxiv : the preprint server | 2026 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | Neuroscientist | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | The Neuroscientist : a review | 2025 | 0 |
| TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the pr [PMID:36368315] | Gratuze M, Schlachetzki JCM, D'Oliveira | Neuron | 2023 | 0 |
| TREM2 receptor protects against complement-mediated synaptic loss by binding to [PMID:37442133] | Zhong L, Sheng X, Wang W, Li Y, Zhuo R, | Immunity | 2023 | 0 |
| TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP- [PMID:34916658] | Xie M, Liu YU, Zhao S, Zhang L, Bosco DB | Nature neuroscience | 2022 | 0 |
| The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's [PMID:35663962] | Qin Q, Wang M, Yin Y, Tang Y | Frontiers in immunology | 2022 | 0 |
| Microglia in Alzheimer's Disease in the Context of Tau Pathology. [PMID:33066368] | ["Perea Juan Ram\u00f3n", "Bol\u00f3s Ma | Biomolecules | 2020 | 0 |
| Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions. [PMID:33028628] | Luhur A, Mariyappa D, Klueg KM, Buddika | G3 (Bethesda, Md.) | 2020 | 0 |
| Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome. [PMID:31261156] | Presta V, Miceli F, Tocci G | Cardiology | 2019 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning APOE-TREM2 interaction in their description or question text
No additional research found