Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ap2a2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | AP2A2 |
| Full Name | Adaptor-Related Protein Complex 2 Subunit Alpha 2 |
| Chromosome | 17p13.2 |
| Protein Type | Gene |
| Function | is a hydrophobic residue) in the cytoplasmic tails of transmembrane proteins are recognized by the mu subunit of AP-2 |
| Primary Expression | the brain, AP2A2 shows particularly high expression in neurons of the cerebral cortex and hippocampus, regions critically involved in learning, memory |
| Molecular Weight | 110 kDa |
| Amino Acids | 050 aa |
| NCBI Gene ID | 161 |
| GeneCards | AP2A2 |
| Human Protein Atlas | AP2A2 |
| Trunk domain | The N-terminal portion of the alpha subunit forms part of the "trunk" region that connects to the rest of the complex |
| Cargo recognition site | Contains motifs that bind to cargo sorting signals on transmembrane proteins |
| Linker region | Connects the trunk to the hinge region |
| Hinge segment | Flexible region that allows conformational changes during the vesicle formation cycle |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["ap2a2 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:AP2A2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:AP2A2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ap2a2 in their description or question text
No additional research found