protein

ANNEXINA11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANNEXINA11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	ANNEXINA11
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	## Role in Disease ### Amyotrophic Lateral SALS (ALS) ANXA11 mutations cause a
Molecular Weight	54 kDa
GeneCards	ANNEXINA11
Human Protein Atlas	ANNEXINA11
Membrane organization	Binds to phospholipid membranes in a calcium-dependent manner
Vesicle trafficking	Regulates exocytosis and endocytosis
[Autophagy](/entities/autophagy)	Involved in autophagosome formation and lysosomal function
[TDP-43](/proteins/tdp-43) binding	Interacts with TDP-43 and influences its localization
Calcium dysregulation	Impaired calcium binding affects neuronal function
TDP-43 mislocalization	Disrupted interaction with TDP-43 leads to nuclear loss
Autophagy defects	Impaired lysosomal function and protein clearance
[Tau](/proteins/tau) pathology	Potential involvement in tau aggregation or clearance
Brainstem vulnerability	Selective susceptibility of brainstem neurons
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Annexin A11 Protein

protein · 606 words

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Pathway Diagram

graph TD
    ANXA11["ANNEXINA11
(Annexin A11)"]
    
    ANXA11 -->|"binds"| CALCIUM["Calcium ions"]
    ANXA11 -->|"associates with"| MEMBRANES["Cell membranes"]
    ANXA11 -->|"regulates"| VESICLE_TRAFFIC["Vesicle trafficking"]
    
    CALCIUM -->|"enables"| MEMBRANE_BIND["Membrane binding"]
    MEMBRANE_BIND -->|"facilitates"| VESICLE_FUSION["Vesicle fusion"]
    
    ANXA11 -->|"interacts with"| CYTOSKELETON["Cytoskeletal proteins"]
    CYTOSKELETON -->|"maintains"| CELL_STRUCTURE["Cell structure integrity"]
    
    ANXA11 -->|"dysfunction leads to"| PROTEIN_AGG["Protein aggregation"]
    PROTEIN_AGG -->|"triggers"| ER_STRESS["ER stress response"]
    ER_STRESS -->|"activates"| UPR["Unfolded protein response"]
    
    PROTEIN_AGG -->|"impairs"| AUTOPHAGY["Autophagy pathway"]
    AUTOPHAGY -->|"fails to clear"| TOXIC_PROTEINS["Toxic protein accumulation"]
    
    TOXIC_PROTEINS -->|"causes"| NEURONAL_DEATH["Neuronal cell death"]
    VESICLE_TRAFFIC -->|"disruption causes"| SYNAPTIC_DYSFUNCTION["Synaptic dysfunction"]
    
    NEURONAL_DEATH -->|"leads to"| NEURODEGENERATION["Neurodegeneration"]
    SYNAPTIC_DYSFUNCTION -->|"contributes to"| NEURODEGENERATION
    
    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:2px
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    
    class ANXA11 central
    class VESICLE_FUSION,CELL_STRUCTURE,AUTOPHAGY protective
    class PROTEIN_AGG,ER_STRESS,TOXIC_PROTEINS,NEURONAL_DEATH,SYNAPTIC_DYSFUNCTION pathological
    class UPR regulatory
    class NEURODEGENERATION disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ANNEXINA11 in their description or question text

No additional research found