Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AD/LATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TARDBP | cross_disease_mechanism_in | gene_or_pathway | 0.86 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TDP-43 RNA-proteostasis failure across ALS, FTD, and AD/LATE | 0.828 | multi | Cross-disease neurodegeneration mechanis |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-28 | 17 hypotheses Top: 0.828
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-lin [PMID:21944779] | Unknown | Neuron | 2011 | 0 |
| TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. [PMID:17469117] | Unknown | Annals of neurology | 2007 | 0 |
| Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic latera [PMID:17023659] | Unknown | Science (New York, N.Y.) | 2006 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning AD/LATE in their description or question text
No additional research found