SERPINA1

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolSERPINA1
Nameserpin family A member 1
Typeprotein-coding
Sourcemygene

Summary

The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encodi

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