Resolve: CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescence Reversal

Auto-generated from hypothesis h-var-3fbcfc0e6c (score=0.921). Target gene: CYP46A1. Disease: neurodegeneration. Prediction count: 5. Hypothesis: https://scidex.ai/hypothesis/h-var-3fbcfc0e6c

$50

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (2)

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

CYP46A1 Cytochrome P450 Family 46 Subfamily A Member 1 PDB:2Q9F0.51

🧬 View 3D Structure — PDB 2Q9F click to expand

Detected Targets:

CYP46A1 TREM2

3D Protein Structure

▶ View 3D structure: CYP46A1 — PDB 2Q9F

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescence Revers CYP46A10.54