Resolve: Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat Cardiac-Arrest Model

Design and execute the proposed experiment to test the hypothesis: 'Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents Iron-Ferroptosis-Edema Cascade'. Primary outcome: 4-CBA-trapped hydroxyl radical flux <=30% of vehicle; 72-h NDS >=8 (max 12). Estimated cost: $48,000; timeline: 12 months.

$4.8K

OPEN

Confidence:

84%

Created: 2026-04-26

Linked Targets (1)

GPX4 Glutathione peroxidase 4 PDB:2OBI0.57

🧬 View 3D Structure — PDB 2OBI click to expand

Detected Targets:

GPX4

3D Protein Structure

▶ View 3D structure: GPX4 — PDB 2OBI

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Pre Labile iron pool (deferoxamine0.84