Resolve: TREM2 Agonist Antibody Rescue of Astrocyte-Microglia Signalling in 5xFAD Mice

Design and execute the proposed experiment to test the hypothesis: 'TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration'. Primary outcome: Reduction of astrocyte A1 markers (C3, Lcn2 mRNA) >=40% vs 5xFAD-vehicle; NOR discrimination index >=0.65. Estimated cost: $85,000; timeline: 18 months.

$6.7K

OPEN

Confidence:

88%

Created: 2026-04-26

Linked Targets (2)

C3 Complement C3 PDB:2A730.67

🧬 View 3D Structure — PDB 2A73 click to expand

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

Detected Targets:

TREM2

3D Protein Structure

▶ View 3D structure: TREM2 — PDB 6YXY

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration TREM20.64