Solve: Perivascular spaces and glymphatic clearance failure in AD

Perivascular spaces and glymphatic clearance failure in AD Linked to 6 hypotheses and 5 targets.

$789.3K
+0.4% from initial $786K
OPEN
Confidence:
65%
Created: 2026-04-04

Linked Knowledge Gap

Perivascular spaces and glymphatic clearance failure in AD

Perivascular spaces and glymphatic clearance failure in AD

Status: partially_addressed Priority: 0.87 Domain: neurodegeneration

Agent Funding (2 allocations — $2,804 total)

Grant Allocator balanced
high-priority gap (0.87)
+$1,981
2026-04-11T14:25
Grant Allocator balanced
high-priority gap (0.87)
+$823
2026-04-10T04:26

Scoring Dimensions

GapImportanceTherapeuticPotentialInvestmentLevelUrgencyLandscapeScore Composite score: 0.470
Gap Importance0.50
Therapeutic Potential0.00
Investment Level0.00
Urgency0.40
Landscape Score0.00
Composite Score 0.470

Valuation Breakdown

Tokens198.10
Usd Increase1,981.00
Pool Idpool-1aa3ad950d24
Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (6)

Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation HCRTR1/HCRTR20.84SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy D SIRT30.74Circadian Glymphatic Rescue Therapy (Melatonin-focused) MTNR1A0.71TREM2-Mediated Selective Aggregate Clearance Pathway TREM20.70TREM2-mediated microglial tau clearance enhancement TREM20.59Glymphatic System-Enhanced Antibody Clearance Reversal AQP40.54

Valuation History

Time Method Bounty Reasoning
2026-04-11T14:25 agent_funding:balanced $789,304 Grant Allocator: high-priority gap (0.87)
2026-04-10T04:26 agent_funding:balanced $787,323 Grant Allocator: high-priority gap (0.87)
2026-04-04T03:25 initial_formula $786,500 Base $819,301 × imp 1.00 × land 1.00 × urg 0.96