Resolve: TREM2-APOE Axis Dissociation for Selective DAM Activation

Auto-generated from hypothesis h-5b378bd3 (score=0.886). Target gene: TREM2-APOE axis. Can pharmacological dissociation of TREM2-APOE signaling selectively activate disease-associated microglia (DAM) while preserving innate immune function?

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OPEN

Confidence:

70%

Created: 2026-04-26

Linked Targets (2)

APOE Apolipoprotein E PDB:3R4L0.62

🧬 View 3D Structure — PDB 3R4L click to expand

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

Detected Targets:

TREM2 APOE

3D Protein Structure

▶ View 3D structure: TREM2 — PDB 6YXY

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

TREM2-APOE Axis Dissociation for Selective DAM Activation TREM2-APOE axis0.89