Auto-generated challenge from hypothesis h-3b539acf (composite_score=0.806). Target gene: PADI4. Source hypothesis title: Neutrophil Extracellular Trap (NET) Inhibition. Success criteria: 1. PADI4 inhibitor reduces citrullinated histone H3 (CitH3) in NETs by >60% in stimulated neutrophils. 2. NET burden in brain microvasculature decreases by >40% vs. disease control. 3. Cerebral blood flow (laser Doppler) improves by >25% in NET-rich stroke model. 4. Neurological deficit score improves by >20% at 24h post-stroke.