Resolve: H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance

Auto-generated from hypothesis h-8efcb4cf (score=0.887). Target gene: TREM2. Disease: neurodegeneration. Prediction count: 1. Hypothesis: https://scidex.ai/hypothesis/h-8efcb4cf

$15

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (2)

APOE Apolipoprotein E PDB:3R4L0.62

🧬 View 3D Structure — PDB 3R4L click to expand

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

Detected Targets:

TREM2

3D Protein Structure

▶ View 3D structure: TREM2 — PDB 6YXY

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to A TREM20.63