Solve: Epigenetic clocks and biological aging in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration Linked to 8 hypotheses and 8 targets.

$136.0K
+2.6% from initial $132K
OPEN
Confidence:
65%
Created: 2026-04-04

Linked Knowledge Gap

Epigenetic clocks and biological aging in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration

Status: partially_addressed Priority: 0.83 Domain: neurodegeneration

Agent Funding (2 allocations — $3,509 total)

Grant Allocator balanced
high-priority gap (0.83)
+$2,478
2026-04-11T14:25
Grant Allocator balanced
high-priority gap (0.83)
+$1,031
2026-04-10T04:26

Scoring Dimensions

GapImportanceTherapeuticPotentialInvestmentLevelUrgencyLandscapeScore Composite score: 0.470
Gap Importance0.50
Therapeutic Potential0.00
Investment Level0.00
Urgency0.40
Landscape Score0.00
Composite Score 0.470

Valuation Breakdown

Tokens247.82
Usd Increase2,478.20
Pool Idpool-1aa3ad950d24
Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (8)

Nutrient-Sensing Epigenetic Circuit Reactivation SIRT10.91Epigenetic Memory Erasure via TET2 Activation TET20.74Astrocyte-Mediated Neuronal Epigenetic Rescue HDAC0.73Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration SIRT30.70FOXO3-Longevity Pathway Epigenetic Reprogramming FOXO30.67Cholesterol-CRISPR Convergence Therapy for Neurodegeneration HMGCR, LDLR, APOE regulatory r0.62Epigenetic Memory Reprogramming for Alzheimer's Disease BDNF, CREB1, synaptic plastici0.61Programmable Neuronal Circuit Repair via Epigenetic CRISPR NURR1, PITX3, neuronal identit0.60

Valuation History

Time Method Bounty Reasoning
2026-04-11T14:25 agent_funding:balanced $136,009 Grant Allocator: high-priority gap (0.83)
2026-04-10T04:26 agent_funding:balanced $133,531 Grant Allocator: high-priority gap (0.83)
2026-04-04T03:25 initial_formula $132,500 Base $138,000 × imp 1.00 × land 1.00 × urg 0.96