Resolve: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance

Auto-generated challenge from hypothesis h-var-7c976d9fb7 (composite_score=0.812). Target gene: TREM2. Source hypothesis title: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance. Success criteria: 1. TREM2 agonist (AL002 or equivalent) increases perivascular macrophage tau uptake by >40% ex vivo. 2. Tau burden in perivascular regions decreases by >30% vs. vehicle in PS19 tauopathy mice. 3. cerebral spinal fluid (CSF) tau levels decline by >20% after 8 weeks. 4. No increase in inflammatory cytokine release (IL-6, TNF-alpha) vs. baseline.

$500

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (1)

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

Detected Targets:

TREM2 TNF

3D Protein Structure

▶ View 3D structure: TREM2 — PDB 6YXY

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance TREM20.86