Auto-generated challenge from hypothesis h-5b35f7a5 (composite_score=0.808). Target gene: HCAR2. Source hypothesis title: Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neuroinflammation. Success criteria: 1. HCAR2 agonist (ND-0701 or equivalent) reduces LPS-induced TNF-alpha release by >40% in primary microglia. 2. Ketone-deficient diet mouse model shows >50% reversal of inflammatory markers with HCAR2 agonist. 3. Synaptic density (PSD95+ puncta) increases by >30% in hippocampal slices. 4. Cognitive improvement (Y-maze) >20% vs. disease control at 8 weeks.