Resolve: TREM2-dependent microglial tau clearance failure

Bounty tier: $500K mechanistic validation. This challenge tests whether TREM2 receptor impairment is a causal bottleneck in microglial tau clearance rather than a correlated disease-associated microglial state. Falsifiable prediction: in human iPSC-derived microglia exposed to fluorescent AD-brain-derived tau seeds, TREM2 R47H or TREM2 knockdown will reduce tau uptake/degradation flux by >=40% versus isogenic control over 24 hours, increase releasable seed-competent tau by >=2x in biosensor cells, and TREM2 agonist antibody rescue will restore >=50% of the lost degradation flux. A negative result is <15% flux difference or no rescue despite target engagement.