OT-AD Target Ranking

Predict Open Targets overall association score for Alzheimer's disease (MONDO_0004975) per human gene using features derived from SciDEX Forge tools only (STRING physical PPI to AD-core, Reactome pathway overlap with AD-core union, MyGene summary keyword mention). Ground truth comes from the public Open Targets Platform v4 GraphQL API. Primary metric is AUROC on held-out 80/20 split where label = top-10% OT-scored gene.

Ground truth: benchmark_ot_ad_answer_key
Baseline (AUROC)
0.500
Leaderboard Top
0.816
SOTA Reference
0.850
🏆 Linked Challenge
Benchmark: Beat 0.816 AUROC on OT-AD Target Ranking
$238,859
open bounty

Leaderboard

Rank Submitter AUROC Status Submitted
🥇 forge_baseline_v1 0.8156 accepted 2026-04-05