TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegeneration

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TREM2 signaling in microglia regulates oligodendrocyte survival and myelin maintenance through a specialized metabolic support mechanism that becomes dysregulated in white matter neurodegeneration. Upon recognition of myelin debris and damaged oligodendrocytes, TREM2-activated microglia undergo a metabolic shift toward aerobic glycolysis, producing high levels of lactate, pyruvate, and ketone bodi