Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Signaling
h-var-e09a2c99ff
The astrocyte-mediated synaptic tagging mechanism operates through coordinated CREB1, S100B, and RAGE (receptor for advanced glycation end products) signaling to regulate synaptic maintenance and protection. Neural activity triggers calcium waves in astrocytes through connexin-43 gap junctions and purinergic P2Y1 receptor activation, leading to calcium/calmodulin-dependent protein kinase II (CaMKI
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| synaptic_biology | 1500 | ±350 | 0-0-0 | 0 |
Ancestry (oldest → this)
mutate · gen 1
parent: h-3e6ca50b2f
Descendants
(no variants yet)