CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Complement Vulnerability Maps

h-var-dbca541049

This hypothesis proposes that the CREB1-BDNF-TrkB activity-dependent transcriptional machinery directly controls the spatial expression patterns of complement regulators CD55 and CD46, creating synaptic vulnerability maps that determine which synapses are targeted for complement-mediated pruning. The mechanism operates through activity-dependent CREB1 phosphorylation at serine 133, which initiates