TREM2-Mediated Spatial Redistribution of Complement Regulators Controls Synaptic Vulnerability

h-var-a7d6fbbb00

TREM2 signaling controls the spatial distribution of complement regulators CD55 and CD46 on synaptic membranes, determining which synapses are vulnerable to complement-mediated pruning. Under normal conditions, TREM2 activation promotes the expression and clustering of CD55/CD46 at perisomatic inhibitory synapses through DAM pathway signaling, while maintaining low regulator density at distal exci