TREM2-Senescence Cascade in Astrocyte-Microglia Communication Breakdown
h-var-a4ec87f152
**Molecular Mechanism and Rationale**
The TREM2-senescence cascade in astrocyte-microglia communication breakdown involves a complex molecular mechanism centered on the triggering receptor expressed on myeloid cells 2 (TREM2) and its downstream signaling partner TYROBP (also known as DAP12). Under physiological conditions, TREM2 functions as a pattern recognition receptor that detects damage-asso
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Ancestry (oldest → this)
crossover · gen 2
parent: h-61196ade × h-var-de1677a080
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