Complement Regulator CD55/CD46 Expression Modulates Microglial Engulfment During Sleep-Wake Cycles

h-var-838f64eb52

The circadian-regulated expression of complement regulators CD55 and CD46 on synaptic membranes establishes a temporal gating mechanism for microglial synaptic engulfment that operates independently of classical complement cascade activation. During wake states, high CD55/CD46 expression creates protective microdomains through direct protein-protein interactions with microglial surface receptors T