TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming

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**Molecular Mechanism and Rationale** The TREM2-CSF1R metabolic cross-talk hypothesis centers on the intricate molecular interactions between triggering receptor expressed on myeloid cells 2 (TREM2) and colony-stimulating factor 1 receptor (CSF1R) signaling cascades that collectively orchestrate microglial metabolic homeostasis. TREM2, a transmembrane glycoprotein predominantly expressed on micro