Novel Hypothesis on Metabolic Dysregulation in Neurodegeneration

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## Mechanistic Overview Novel Hypothesis on Metabolic Dysregulation in Neurodegeneration rests on the following mechanistic claim: This hypothesis proposes that mitochondrial dysfunction in astrocytes represents a critical upstream driver of neurodegeneration in Alzheimer's disease through disruption of lactate shuttling to neurons. Specifically, we hypothesize that accumulation of amyloid-beta ol