Epigenetic Silencing of Tumor Suppressor Genes in Cancer Progression

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## Mechanistic Overview Epigenetic Silencing of Tumor Suppressor Genes in Cancer Progression rests on the following mechanistic claim: This hypothesis proposes that hypermethylation of CpG islands in the promoter region of the TP53 tumor suppressor gene leads to transcriptional silencing and subsequent loss of p53 function in colorectal cancer development. The p53 protein normally acts as a critic