TREM2-Dependent Senescent Microglia Disrupt Astrocyte Communication Networks

h-var-42a172bc53

## **Molecular Mechanism and Rationale** The proposed mechanism centers on the TREM2 (Triggering Receptor Expressed on Myeloid cells 2) and its adapter protein TYROBP (DNAX-activation protein 12, DAP12) signaling axis as a critical regulator of microglial homeostasis and cellular senescence resistance. TREM2 is a transmembrane glycoprotein receptor exclusively expressed on microglia within the ce