TREM2-Mediated Astroglial Reactivity in Neurodegeneration

h-var-223b8be521

## **Molecular Mechanism and Rationale** The TREM2-mediated astroglial reactivity hypothesis centers on a complex molecular cascade initiated by TREM2 (Triggering Receptor Expressed on Myeloid cells 2) signaling through its adaptor protein TYROBP (also known as DAP12). TREM2 is a single-pass transmembrane receptor belonging to the immunoglobulin superfamily, predominantly expressed on microglia w