Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Overexpression

h-var-159030513d

**Molecular Mechanism and Rationale** The NAD+ salvage pathway represents a critical metabolic hub in neuronal energy homeostasis, with NAMPT functioning as the pivotal rate-limiting enzyme that governs cellular NAD+ availability. NAMPT catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate (PRPP) to generate nicotinamide mononucleotide (NMN), which serves as the immedia