Dynamic Microglial Phenotype Switching Biomarker Panel for Neuroinflammatory Treatment Stratification

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**Molecular Mechanism and Rationale** The molecular foundation of this biomarker panel centers on the intricate interplay between TREM2 (Triggering Receptor Expressed on Myeloid Cells 2), YKL-40 (Chitinase-3-like protein 1), and GPNMB (Glycoprotein Non-Metastatic Melanoma Protein B) in orchestrating microglial phenotype transitions during neurodegeneration. TREM2, a transmembrane glycoprotein exc