Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization

h-var-002f522b52

The activity-dependent trafficking of complement regulators CD55 and CD46 to synaptic surfaces represents a dynamic regulatory mechanism controlling complement-mediated synaptic pruning through vesicular transport and membrane insertion. Rather than static differential expression, CD55 and CD46 undergo rapid, activity-dependent translocation from intracellular vesicular pools to synaptic membranes