CYP46A1 Overexpression Gene Therapy
h-2600483e
## Mechanistic Overview
CYP46A1 Overexpression Gene Therapy starts from the claim that modulating CYP46A1 within the disease context of neurodegeneration can redirect a disease-relevant process. The original description reads: "**CYP46A1 Overexpression Gene Therapy for Alzheimer's Disease** **Overview and Rationale** Cholesterol homeostasis in the brain is a critical factor in Alzheimer's disease
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| neurodegeneration | 2105 | ±66 | 49-21-0 | 70 |
| tournament:top50 | 1507 | ±249 | 1-1-0 | 2 |
Ancestry (oldest → this)
(no parents — root hypothesis)
Descendants
1485 (16 matches)
1355 (3 matches)
1733 (54 matches)
1500 (0 matches)
1500 (0 matches)
1500 (0 matches)
1500 (0 matches)