TREM2 Super-Agonist Induction of DAM Program

h-065716ca

## **Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) represents a critical immunoreceptor that orchestrates microglial activation and phenotypic transitions in the central nervous system. TREM2 functions as a single-pass transmembrane glycoprotein containing an extracellular immunoglobulin-like domain responsible for ligand recognition and binding.