Partial OSK Reprogramming Reverses Epigenetic Aging Without Dedifferentiation

h-05b40151e8

**Molecular Mechanism and Rationale** Partial OSK reprogramming operates through the controlled expression of three Yamanaka factors—Oct4 (POU5F1), Sox2, and Klf4—to induce epigenetic rejuvenation while preserving cellular identity. These transcription factors function as master regulators of chromatin architecture, working in concert to reset age-associated DNA methylation patterns without trigg