Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular efficacy if neuroinflammation is central?
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The debate noted clinical failures of TNF-α and IL-6 inhibitors in AD despite their cardiovascular success and shared inflammatory pathways. This paradox suggests unknown mechanist...
Top Hypothesis
Compensatory Cytokine Network Activation
🧬 AQP4🏥 clinical neurology🧬 LRP1🧬 NLRP3
clinical neurology
2026-04-08
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Debate→Hypotheses→Evidence→KG
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