Goal
Run or backfill substantive debates for therapeutic targets with no debate coverage. Target debates harden prioritization before markets and allocation proposals rely on target scores.
Acceptance Criteria
☑ A concrete batch of targets with debate_count = 0 receives target debate coverage
☑ Each debate includes substantive pro, con, and synthesis content tied to target evidence
☑ target_debates rows or target debate_count values are verified
☑ Before/after undebated target counts are recorded
Approach
Select targets with debate_count = 0, prioritizing high composite, portfolio, or allocation scores.
Use the existing target debate workflow or create target_debates from substantive review output.
Tie debate rationale to target evidence, drugs, clinical trials, KG edges, and safety context.
Verify target_debates rows, debate_count updates, and remaining backlog.Dependencies
c488a683-47f - Agora quest
Dependents
- Target prioritization, Agora debate coverage, and Exchange market confidence
Work Log
2026-04-21 - Quest engine template
- Created reusable spec for quest-engine generated target debate backfill tasks.
2026-04-21 13:30 UTC - Task 12789213-9215-4be2-994d-6e53419f72a2
Task completed successfully. Created scripts/run_target_debates.py to backfill target debates.
Results:
- Before: 185 targets with debate_count = 0
- After: 159 targets with debate_count = 0 (26 now debated)
- 25 new target debates created via LLM-powered 4-persona debate (theorist/skeptic/expert/synthesizer)
- Debated targets include: GABRA1, LDLR, CACNA1G, DRD2, IDH2, P2RX7, BCL2L1, MTNR1A, RAB7A, PRKAA1, KCNK2, C3, PARP1, TH, IL1B, P2RY1, MTNR1B, NLRP3, G3BP1, GLP1R, HSP90AA1, PDGFRB, TREM2, CGAS, APOE, ADORA2A
- Each debate produces pro/con/synthesis JSON with overall_assessment score
- target_debates rows created linking debate sessions to targets
- debate_count updated on each target
Verification:
- 26 targets have debate_count > 0 (exceeds requirement of 25)
- 159 targets without debate (≤ 160 as required)
- target_debates rows verified in database
2026-04-21 22:10 UTC - Task de55ca6b-826e-4fd1-89a7-cd911ca8f0cd
Task completed successfully. Reused scripts/run_target_debates.py to run a follow-on batch of target debates for the next 25 highest-composite undebated therapeutic targets.
Results:
- Before: 159 targets with
debate_count = 0, 26 targets with debate coverage, 26 target_debates rows.
- After: 134 targets with
debate_count = 0, 51 targets with debate coverage, 51 target_debates rows.
- 25 new target debates persisted with 0 failures.
- Debated targets: SLC7A11, HSPA1A, ADRA2A, ULK1, SNCA, HCRTR1, FCGRT, HCRTR2, P2RY12, LOX, CX3CR1, SIRT6, TGM2, TFR1, CD38, C1Q, BDNF, FKBP5, MMP9, NR3C1, TET2, TUBB3, STX17, TLR4, TFRC.
- Each new debate has a linked
target_debates row, completed debate_sessions row, 4 transcript rounds, and substantive pro/con/synthesis content tied to target evidence.
Verification:
python3 scripts/run_target_debates.py --limit 25 --min-success 25 exited 0 with successes = 25, failures = [], and remaining_without_debate = 134.- Database check: 134 targets remain with
COALESCE(debate_count, 0) = 0; 51 targets have debate_count > 0; 51 distinct targets are linked in target_debates; 51 target debate sessions exist.
- New-row audit since
2026-04-21 20:58:00+00: 25 rows; every row has status = completed, rounds = 4, and transcript length between 36,629 and 53,848 characters.
- Content spot check: SLC7A11 transcript includes explicit pro rationale around ferroptosis/glutathione/GPX4, con rationale around inhibition-vs-activation translational risk, and synthesis JSON with evidence-backed claims.
Already Resolved — 2026-04-21 23:55:00Z
Verified task is already complete on main. Evidence:
psql query: 62 targets with debate_count > 0, 123 undebated targets (≤ 134 required ✓), 62 target_debates rows- Content spot-checked PPARGC1A transcript: 4 rounds (theorist/skeptic/domain_expert/synthesizer), substantive pro/con/synthesis with PMIDs and evidence scores
- Per spec work log, task
de55ca6b-826e-4fd1-89a7-cd911ca8f0cd was completed at 2026-04-21 22:10 UTC with 25 new debates added
- Current state maintains ≥ 25 debated targets (now 62) and ≤ 134 undebated (now 123) — acceptance criteria satisfied