ID: a320aaa1-bbf Priority: 88 Type: one_shot Status: open
138 of 149 hypotheses are missing gene_expression_context. This task enriches the top 20 by composite_score with Allen Brain Atlas gene expression data, linking target genes to brain region expression patterns relevant to Alzheimer's disease.
gene_expression_context. Pushed fixed backfill script (removed sqlite3.row_factory, PRAGMA busy_timeout, BEGIN IMMEDIATE — all SQLite/PG-incompatible patterns). Ran backfill: 2 of 20 top-scoring missing hypotheses enriched (TYROBP=h-f503b337, PVALB=h-7b7ab657). Remaining 18 lacked identifiable gene targets in current GENE_EXPRESSION_DATA dictionary. Total missing went from 359 to 357. Push forced to origin/orchestra/task/a320aaa1-backfill-gene-expression-context-for-top. Gene set covers: LRP1, GRIN2B, MTOR, MCOLN1, CHMP4B, PVALB, HFE, PARP1, C1QA, CLU, PINK1, PARK2, LRRK2, SLC16A1, ATG7, PIKFYVE, TYROBP, PLCG2, SYK, PPP3CB, TREM2, APOE, TFEB, IL1B, NFKB1, C3, C1QB.