[Exchange] Enrich 7 thin EC Layer II vulnerability hypotheses with deep descriptions and evidence

[Exchange] Enrich 7 thin EC Layer II vulnerability hypotheses with deep descriptions and evidence

ID: 24d68b79-e09 Priority: 91 Type: one_shot Status: open

Goal

[Exchange] Enrich 7 thin EC Layer II vulnerability hypotheses with deep descriptions and evidence

Acceptance Criteria

Work Log

2026-04-26 00:45 UTC — Verification (claude-auto:42)

Status: DB enrichment already complete — verified in PostgreSQL.

Prior run (orphan commit 00cdc6574367f99622496d63ab5b6105f96bf613, never merged to main) wrote
evidence addendums directly to PostgreSQL. The DB changes survived because PostgreSQL persists
independently of git. The task system itself confirmed success on 2026-04-21T02:58:37 UTC with
verification_notes: "evidence_validation_score=0.78, last_evidence_update populated, 7
task-scoped db_write_journal rows."

7 target EC Layer II vulnerability hypotheses verified in production DB (2026-04-26):

ID	Title (truncated)	Desc len	Evidence addendum	Score
h-var-d33964b962	Real-time gamma-guided tFUS targeting EC-II SST...	20 923	✅ present	0.78
h-var-4eca108177	Closed-loop tACS targeting EC-II PV interneurons...	21 206	✅ present	0.78
h-var-f110ef2e0a	Closed-loop tFUS targeting EC-II SST (tau propagation)	21 367	✅ present	0.78
h-var-d98a992599	Closed-loop tACS targeting EC-II SST (AMPK-autophagy)	21 994	superseded → 1.0	1.00
h-var-b7e4505525	Closed-loop tFUS targeting EC-II SST (perforant path)	29 321	✅ present	0.78
h-var-abcd9e77ce	Closed-loop tFUS targeting entorhinal PV interneurons	29 247	✅ present	0.78
h-var-6e963ed4e6	Closed-loop tACS targeting EC-II SST (HCN/dendritic)	30 092	✅ present	0.78

Evidence addendum content: Each addendum includes PubMed-backed mechanistic evidence for the
EC Layer II vulnerability shared evidence base — Braak staging, tau seeding in
transentorhinal/entorhinal tissue, layer II entorhinal neurons as selectively vulnerable
population (PMID: 39435008, and related references).

Page health: All 7 hypothesis pages return HTTP 200 (via 301 redirect to canonical URL).

Notes:

• 6 of 7 retain the ## Evidence enrichment addendum section.
• h-var-d98a992599 was subsequently enriched by another task to score=1.0 (still fully rich

at 21 994 chars); its addendum was replaced by a more complete description.

• The DB is the authoritative deliverable; no code changes are required.

Already Resolved — 2026-04-26 00:45 UTC

Evidence: Direct PostgreSQL query confirmed 7 EC Layer II hypothesis IDs have last_evidence_update set between 2026-04-20 and 2026-04-21 UTC, 6 with evidence_validation_score=0.78 and ## Evidence enrichment addendum in descriptions. The
7th (h-var-d98a992599) was upgraded to 1.0 by a subsequent enrichment pass.

Prior fix: Orphan commit 00cdc6574367f99622496d63ab5b6105f96bf613 (never merged to git
main, but DB writes persisted in PostgreSQL).

Summary: DB enrichment complete; all 7 EC Layer II vulnerability hypotheses have deep
descriptions and PubMed-backed evidence addendums in production.

Tasks using this spec (1)

[Exchange] Enrich 7 thin EC Layer II vulnerability hypothese

File: 24d68b79_e09_spec.md

Modified: 2026-04-25 23:40

Size: 3.2 KB