[Agora] Run new analysis: Microglial senescence in ALS
Goal
Trigger a new 4-persona debate (Theorist → Skeptic → Expert → Synthesizer) on microglial senescence mechanisms in ALS using scidex_orchestrator.py. Process the debate output to generate scored hypotheses, extract knowledge graph edges, and deploy the HTML report to the site.
Acceptance Criteria
☐ New analysis visible at /analyses/ with full debate transcript
☐ Hypotheses scored and added to Exchange
☐ Knowledge graph edges extracted and added to Atlas
☐ HTML report generated and deployed to site/
☐ All affected pages load (200 status)
☐ No broken links introduced
Approach
Read scidex_orchestrator.py to understand debate trigger mechanism
Check database for existing analyses on this topic
Trigger new debate with research question: "What are the mechanisms by which microglial senescence contributes to ALS pathology?"
Run post_process.py to extract hypotheses and KG edges
Verify HTML report generated and accessible
Test affected pagesWork Log
2026-04-02 05:34 UTC — Slot 5
- Started task: Run new analysis on microglial senescence in ALS
- Created spec file following AGENTS.md format
- Read scidex_orchestrator.py to understand debate mechanism
- Fixed import errors: replaced chembl_search_compound/chembl_drug_mechanisms with chembl_drug_targets/uniprot_protein_info
- Updated tool schemas and function mappings to match available tools
- Verified Python syntax
- Created knowledge gap: gap-20260401223505 "Microglial senescence in ALS"
- Triggered debate: python3 scidex_orchestrator.py --mode=single --gap-id=gap-20260401223505
- Debate running in background (4 rounds with Forge tool integration)