APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.
2025
10.1101/2024.04.25.591140. APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition. Naguib S(1)(2), Lopez-Lee C(1)(3)(2), Torres ER(1)(2), Lee SI(1), Zhu J(1), Zhu D(1), Ye P(1), Norman K(1), Zhao M(1), Wong MY(1), Ambaw YA(4), Castaneda R(1), Wang W(1), Patel T(5), Bhagwat M(1), Norinsky R(6), Mok SA(5), Walther TC(7), Farese RV(4), Luo W(1), Sinha S(1), Wu Z(1), Fan L(1), Gong S(1), Gan L(1)(3).