Notebook Artifact Registry

Computational analysis artifacts linked to analyses and knowledge graph entities

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Gene Expression Changes in Aging Mouse Brain Predicting Neurodegenerative Vulnerability

Real Forge-powered analysis: PubMed search, STRING PPI, Reactome pathways, gene annotations for aging mouse brain transcriptomics.

showcase forge-tools transcriptomics neurodegeneration

📊 Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability

Created: 2026-04-16

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Neuroinflammation and Microglial Priming in Early Alzheimer's Disease

Real Forge-powered analysis: PubMed search, STRING PPI, Reactome pathways, gene annotations for microglial priming in early AD.

showcase forge-tools neuroinflammation neurodegeneration

📊 Neuroinflammation and microglial priming in early Alzheimer's Disease

Created: 2026-04-16

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CRISPR-Based Therapeutic Approaches for Neurodegenerative Diseases

Real Forge-powered analysis: PubMed search, STRING PPI, Reactome pathways, gene annotations for CRISPR neurodegeneration therapy research.

showcase forge-tools gene-editing neurodegeneration

📊 CRISPR-based therapeutic approaches for neurodegenerative diseases

Created: 2026-04-16

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Mitochondrial Dysfunction as a Driver of Neurodegeneration

How does mitochondrial dysfunction drive neurodegeneration across AD, PD, and ALS? Characterize PINK1/Parkin mitophagy pathway, mtDNA damage, ETC complex activity, and ROS generati

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Created: 2026-04-13

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Tau Pathology Propagation in Tauopathies — Mechanistic Dissection

How does misfolded tau spread through the brain in tauopathies? Characterize prion-like propagation mechanisms, cell-to-cell transfer, and the role of MAPT mutations, ApoE genotype

[]

Created: 2026-04-13

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All Notebooks (3) (filtered by: Aging)

Senescent cell clearance as neurodegeneration therapy - Analysis Notebook

Gene expression analysis notebook for Can senolytics targeting senescent cells slow neurodegeneration?

Aging Senolytics Therapeutics Senescent Cells

CDKN2A CDKN1A TP53 RB1 BCL2

📊 Senescent cell clearance as neurodegeneration therapy (neurodegeneration)

Created: 2026-04-02

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Epigenetic reprogramming in aging neurons - Rich Analysis Notebook

Executed notebook with gene expression plots, pathway enrichment, radar charts, and statistical tests for: Investigate mechanisms of epigenetic reprogramming in aging neurons...

Aging Epigenetics Gene Expression Neurodegeneration

📊 Epigenetic reprogramming in aging neurons (neurodegeneration)

Created: 2026-04-02

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Aging Mouse Brain Atlas: Cross-Age Gene Expression Analysis

Differential expression analysis across hippocampus, cortex, and cerebellum in young, middle-aged, and old mice. Identifies aging-neurodegeneration overlap with 5 testable hypotheses.

Aging Mouse Model Gene Expression Neurodegeneration Cross-Age Analysis

APOE TREM2 GFAP SYP TFAM

Created: 2026-04-02

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