How does Alectinib, a kinase inhibitor, achieve high-affinity binding to complement protein C1q? — Analysis Notebook

CI-generated notebook stub for analysis SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e. The abstract reports that Alectinib binds C1q with high affinity, but this is mechanistically unexpected since Alectinib is designed as a kinase inhibitor while C1q is a complement

📊 Related Analysis: How does Alectinib, a kinase inhibitor, achieve high-affinity binding to complement protein C1q? (neuroinflammation)

Notebook Overview

Cells
29
Markdown
15
Code
14
Executed
14
Output Cells
13
Kernel
Python 3
Language
python 3.13.12
Notebook
v4.5
Created: 2026-04-18
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MarkdownHow does Alectinib, a kinase inhibitor, achieve high-affinity binding to cMarkdownDebate SummaryMarkdown1. Target gene annotations (MyGene)Codeimport pandas as pdIn [1]Markdown2. GO Biological Process enrichment (Enrichr)Codego_bp = [{'rank': 1, 'term': 'Regulation Of Interleukin-6 Production (GO:0In [2]Codeimport matplotlib.pyplot as pltIn [3]Markdown3. STRING protein interaction networkCodeppi = [{'protein1': 'CRP', 'protein2': 'FCGR1A', 'score': 0.434, 'nscore':In [4]Codeimport mathIn [5]Markdown4. Reactome pathway footprintCodepw_rows = [{'gene': 'ALK', 'n_pathways': 8, 'top_pathway': 'Signaling by AIn [6]Markdown5. Hypothesis ranking (5 hypotheses)Codehyp_data = [('Selective C1q-CRP vs. C1q-IgG Axis Inhibition', 0.599), ('CoIn [7]Codelabels = ['Selective C1q-CRP vs. C1q-IgG Axis Inhib', 'Combined NAMPT-AlecIn [8]Markdown6. PubMed literature per hypothesisMarkdownHypothesis 1: Selective C1q-CRP vs. C1q-IgG Axis InhibitionCodeprint('No PubMed results for hypothesis h-c8d2ea20')In [9]MarkdownHypothesis 2: Combined NAMPT-Alectinib Targeting of SASP-Complement CascadCodeprint('No PubMed results for hypothesis h-292a1ec3')In [10]MarkdownHypothesis 3: Alectinib-C1q Complex Hijacks TREM2's Synaptic Protective BiCodeprint('No PubMed results for hypothesis h-d9c5a529')In [11]MarkdownHypothesis 4: Kinase Inhibitor-C1q Structural Convergence for BifunctionalCodeprint('No PubMed results for hypothesis h-5d753df0')In [12]MarkdownHypothesis 5: Microglial Membrane Camouflage Exploits CD47-SIRPα CheckpoinCodeprint('No PubMed results for hypothesis h-f5518156')In [13]Markdown7. Knowledge graph edges (1 total)Codeedge_data = [{'source': 'C1QA/C1QB/C1QC, CRP, FCGR1A', 'relation': 'promotIn [14]
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