Research Question: The study reports that complement-mediated synaptic elimination produces both cognitive deficits and anxiety-like behaviors, but doesn't explain how the same hippocampal synaptic loss generates these distinct behavioral phenotypes. This mechanistic gap limits understanding of perioperative neurocognitive disorders. Gap type: unexplained_observation Source paper: Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysf