Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data) — Analysis Notebook

CI-generated notebook stub for analysis SDA-2026-04-03-gap-seaad-v4-20260402065846. What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transcriptomic data from the Allen Brain Cell Atlas? Identify mechanisms of cell-type-specific vulnerabili

📊 Related Analysis: Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data) (neurodegeneration)

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Cells
58
Markdown
30
Code
28
Executed
28
Output Cells
27
Kernel
Python 3
Language
python 3.13.12
Notebook
v4.5
Created: 2026-04-16
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Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)Debate Summary1. Target gene annotations (MyGene + Human Protein Atlas)2. GO Biological Process enrichment (Enrichr)3. STRING protein interaction network4. Reactome pathway footprint5. Hypothesis ranking (19 hypotheses)6. Score dimension heatmap (top 10)7. PubMed literature per hypothesisHypothesis 1: ACSL4-Mediated Neuroinflammatory Amplification in Disease-Associated MHypothesis 2: ACSL4-Driven Ferroptotic Priming in Disease-Associated MicrogliaHypothesis 3: ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White MaHypothesis 4: 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to SeHypothesis 5: Microglial TREM2-SYK Pathway EnhancementHypothesis 6: ACSL4-Driven Ferroptotic Priming in Disease-Associated OligodendrocyteHypothesis 7: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic PrimHypothesis 8: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PEHypothesis 9: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate PooHypothesis 10: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic VulnerabilitHypothesis 11: SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Hypothesis 12: Selective Tau Kinase Inhibition in Vulnerable Neuronal SubtypesHypothesis 13: Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic UncouplingHypothesis 14: Astrocyte APOE4-Specific Lipid Metabolism CorrectionHypothesis 15: Cell-Type Specific Metabolic ReprogrammingHypothesis 16: Disease-Associated Microglia Metabolic ReprogrammingHypothesis 17: Spatially-Targeted Regional Vulnerability PreventionHypothesis 18: Vascular-Glial Interface RestorationHypothesis 19: Oligodendrocyte DNA Repair Enhancement8. Knowledge graph edges (201 total)Caveats

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MarkdownCell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)MarkdownDebate SummaryMarkdown1. Target gene annotations (MyGene + Human Protein Atlas)Codeimport pandas as pdIn [1]Markdown2. GO Biological Process enrichment (Enrichr)Codego_bp = [{'rank': 1, 'term': 'Microglial Cell Activation (GO:0001774)', 'pIn [2]Codeimport matplotlib.pyplot as pltIn [3]Markdown3. STRING protein interaction networkCodeppi = [{'protein1': 'APOE', 'protein2': 'MAPT', 'score': 0.879, 'nscore': In [4]Codeimport mathIn [5]Markdown4. Reactome pathway footprintCodepw_rows = [{'gene': 'ACSL4', 'n_pathways': 2, 'top_pathway': 'IntracellulaIn [6]Markdown5. Hypothesis ranking (19 hypotheses)Codehyp_data = [('ACSL4-Mediated Neuroinflammatory Amplification in Disea', 0)In [7]Markdown6. Score dimension heatmap (top 10)Codelabels = ['ACSL4-Mediated Neuroinflammatory Amplifi', 'ACSL4-Driven FerropIn [8]Markdown7. PubMed literature per hypothesisMarkdownHypothesis 1: ACSL4-Mediated Neuroinflammatory Amplification in Disease-AsCodelit_data = [{'year': '2025', 'journal': 'Phytomedicine', 'title': 'IntegraIn [9]MarkdownHypothesis 2: ACSL4-Driven Ferroptotic Priming in Disease-Associated MicroCodelit_data = [{'year': '2025', 'journal': 'Phytomedicine', 'title': 'IntegraIn [10]MarkdownHypothesis 3: ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes DriveCodelit_data = [{'year': '2025', 'journal': 'Phytomedicine', 'title': 'IntegraIn [11]MarkdownHypothesis 4: 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic PriCodelit_data = [{'year': '2025', 'journal': 'Phytomedicine', 'title': 'IntegraIn [12]MarkdownHypothesis 5: Microglial TREM2-SYK Pathway EnhancementCodeprint('No PubMed results for hypothesis h-48858e2a')In [13]MarkdownHypothesis 6: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo
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