Clinical experiment designed to assess clinical efficacy targeting N/A in human patients undergoing thoracoscopic lung cancer surgery. Primary outcome: incidence of chronic postsurgical pain at 3 months
This randomized controlled trial investigated whether early postoperative repetitive transcranial magnetic stimulation (rTMS) could reduce chronic postsurgical pain (CPSP) in older patients undergoing thoracoscopic lung cancer surgery. The study targeted the left dorsolateral prefrontal cortex with high-frequency rTMS (10 Hz, 100% resting motor threshold, 2000 pulses per session) administered immediately after extubation in the post-anesthesia care unit. The trial followed 198 patients for 3 months to assess clinical outcomes including CPSP incidence, anxiety, depression scores, and inflammatory biomarkers. The intervention aimed to prevent the development of chronic pain through neuromodulation of pain processing circuits in the brain.
Randomized controlled trial with 286 patients screened, 230 randomized to active or sham rTMS targeting left DLPFC (10 Hz, 100% RMT, 2000 pulses) immediately post-extubation. 3-month follow-up with blinded evaluators assessing clinical and biochemical outcomes.
Reduction in CPSP incidence, improved anxiety and depression scores, decreased inflammatory biomarkers
Significant reduction in CPSP incidence compared to sham group
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