Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about cGAS (CGAS), STING (TMEM173): its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| cGAS-STING Pathway Hyperactivation Mediates Tau Propagation | 0.760 | neurodegeneration | Gap 006 analysis (archived stub) |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164] | Unknown | 2025 | 0 | |
| The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238] | Unknown | 2025 | 0 | |
| Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133] | Hyde VR, Zhou C, Fernandez JR, Chatterje | Cell reports | 2025 | 0 |
| Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433] | Carling GK, Fan L, Foxe NR, Norman K, Wo | Neuron | 2024 | 0 |
| Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623] | ["Jin Meihua", "Shiwaku Hiroki", "Tanaka | Nature communications | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning cGAS (CGAS), STING (TMEM173) in their description or question text
No additional research found