Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about autophagy restoration: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | protects_against | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE-Dependent Autophagy Restoration | 0.850 | neurodegeneration | Mechanistic role of APOE in neurodegener |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-10 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-NPC effects on astrocytes in vitro ICH model | exploratory | intracerebral hemorrhage | 0.900 | 0.00 | in vitro ICH cell culture mode | proposed | N/A |
| AMPK knockdown validation experiment | exploratory | intracerebral hemorrhage | 0.880 | 0.00 | astrocyte cell culture | proposed | N/A |
| P2RY12-MTOR pathway interaction in VSMCs | exploratory | atherosclerosis | 0.850 | 0.00 | cultured VSMCs | proposed | N/A |
| iPSC-NPC transplantation in ICH animal model | validation | intracerebral hemorrhage | 0.850 | 0.00 | animal ICH model | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253] | Koenig J, McGuire A, Homedan Y, Alberhas | eNeuro | 2026 | 0 |
| S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800] | Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu | Molecular and cellular biochem | 2026 | 0 |
| Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190] | Li J, Li J, Chen K | Mol Ther | 2026 | 0 |
| Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169] | Li Z, Yang X, Mao J, Zeng P, Qi Y et al. | Autophagy | 2026 | 0 |
| Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091] | Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a | Cancer Res | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential [PMID:41789635] | Huo R, Yang Y, Wei C, Yang Y, Meng D et | Int J Mol Med | 2026 | 0 |
| Microcystin-LR-induced phosphorylation imbalance and organelle stress: An integr [PMID:41846138] | Teng Z, Shahzad A, Xu Z, Xia J, Zhang J | J Hazard Mater | 2026 | 0 |
| Copper deficiency impairs oligodendrocyte maturation and social behavior via mit [PMID:41920999] | Usui N, Doi M, Berto S, Matsuoka K, Ishi | Sci Adv | 2026 | 0 |
| Crosstalk between inflammation and autophagy in CeD organoids. [PMID:41933042] | Bellomo C, Furone F, Auricchio R, D'Anie | Sci Rep | 2026 | 0 |
| Targeting the AKT/mTOR axis: pectolinarigenin induces autophagy and apoptosis in [PMID:41924135] | Fang Y, Bai J, Bo S, Cui X, Song H, Guo | Frontiers in pharmacology | 2026 | 0 |
| Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsi [PMID:41922823] | Alshaikh ABA, Al-Kuraishy HM, Abdelaziz | Naunyn-Schmiedeberg's archives | 2026 | 0 |
| Platelet proteomic signatures of amyloid β-positive mild cognitive impairment an [PMID:41904574] | Cho YE, Kim A, Lee HM, Oh JW, Son SJ, Ro | Molecular brain | 2026 | 0 |
| Targeting of the PI3K/AKT/mTOR signaling pathway in the neurovascular interface [PMID:41865874] | Alameen AAM, Al-Kuraishy HM, Al-Gareeb A | Microvascular research | 2026 | 0 |
| Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200] | ["Khanal P", "Balmik A"] | CNS & neurological disorders d | 2026 | 0 |
| Aromatic amino acid metabolism shapes autophagy-mediated adaptation to iron depr [PMID:41925978] | Zhao K, Ludwig-Radtke L, Wang Y, Rusch T | Biometals : an international j | 2026 | 0 |
| iPSC-NPC transplantation alleviates brain injury after intracerebral hemorrhage [PMID:41921697] | Zhong Z, Wang S, Xu C, Liu Q, Chen X, Li | Journal of stroke and cerebrov | 2026 | 0 |
| Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegen [PMID:39779911] | Zhang L, Xu Z, Jia Z, Cai S, Wu Q, Liu X | Nature aging | 2025 | 0 |
| Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010] | Torrini C, Nguyen TTT, Shu C, Mela A, Hu | Molecular cell | 2022 | 0 |
| Brain-restricted mTOR inhibition with binary pharmacology. [PMID:36104566] | Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, | Nature | 2022 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning autophagy restoration in their description or question text
No additional research found